Cells, Free Full-Text
Por um escritor misterioso
Descrição
Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation. It is important to delineate the regulatory control of lncRNA degradation, particularly for lncRNA telomeric repeat-containing RNA (TERRA), as the TERRA-telomere R-loops dictate cell cycle progression and genomic stability. We now report that the exosome complex component Exosc9 degrades lncRNA TERRA in human mammary epithelial cells. Heterochromatin protein 1 alpha (HP1α) recruits Exosc9 to the telomeres; specifically, the SUMO-modified form of HP1α supports interaction with Exosc9 and, as previously reported, lncRNA TERRA. The telomeric enrichment of Exosc9 is cell cycle-dependent and consistent with the loss of telomeric TERRA in the S/G2 phase. Elevated Exosc9 is frequently observed and drives the growth of endocrine therapy-resistant (ET-R) HR+ breast cancer (BCa) cells. Specifically, the knockdown of Exosc9 inversely impacts telomeric R-loops and the integrity of the chromosome ends of ET-R cells. Consistently, Exosc9 levels dictate DNA damage and the sensitivity of ET-R BCa cells to PARP inhibitors. In this regard, Exosc9 may serve as a promising biomarker for predicting the response to PARP inhibitors as a targeted monotherapy for ET-R HR+ BCa.
![Cells, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S1567724923000387-gr1.jpg)
MitoQuicLy: A high-throughput method for quantifying cell-free DNA
![Cells, Free Full-Text](https://www.researchgate.net/publication/336251322/figure/fig1/AS:810118572670976@1570158727784/An-illustration-of-the-full-duplex-cell-free-massive-MIMO-system.png)
An illustration of the full-duplex cell-free massive MIMO system
![Cells, Free Full-Text](https://iiif.elifesciences.org/lax/70520%2Felife-70520-fig3-v2.tif/full/,1500/0/default.jpg)
Remote immune processes revealed by immune-derived circulating
![Cells, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S2666634021000313-fx1.jpg)
Cell-free DNA tissues of origin by methylation profiling reveals
![Cells, Free Full-Text](https://www.mdpi.com/viruses/viruses-07-02953/article_deploy/html/images/viruses-07-02953-g001.png)
Viruses, Free Full-Text
![Cells, Free Full-Text](https://iiif.elifesciences.org/lax/70520%2Felife-70520-fig2-v2.tif/full/,1500/0/default.jpg)
Remote immune processes revealed by immune-derived circulating
![Cells, Free Full-Text](https://www.researchgate.net/profile/Natalio-Krasnogor/publication/282702033/figure/fig2/AS:286568797093889@1445334733772/Scheme-of-cell-free-cloning-using-DMF-A-The-full-length-construct-generated-by-POP.png)
Scheme of cell free cloning using DMF. ( A ) The full length
THE LIVES OF A CELL : LEWIS THOMAS : Free Download, Borrow, and
![Cells, Free Full-Text](https://i0.wp.com/www.mdpi.com/cells/cells-08-00886/article_deploy/html/images/cells-08-00886-g003.png?w=1920&ssl=1)
Harnessing Extracellular Vesicles for Regenerative Therapy
![Cells, Free Full-Text](https://www.thelancet.com/cms/attachment/9f2b8728-20bd-4a53-bd20-fa9ba641500d/gr1.jpg)
Cells, Free Full-Text
![Cells, Free Full-Text](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-018-25532-3/MediaObjects/41598_2018_25532_Fig1_HTML.jpg)
Anomalous Scaling of Gene Expression in Confined Cell-Free
![Cells, Free Full-Text](https://library.weill.cornell.edu/sites/default/files/pmc1.png)
Cells, Free Full-Text
![Cells, Free Full-Text](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-021-25233-y/MediaObjects/41467_2021_25233_Fig1_HTML.png)
An integrated in vivo/in vitro framework to enhance cell-free
![Cells, Free Full-Text](https://www.biorxiv.org/content/biorxiv/early/2022/04/06/2022.04.06.487251/F1.large.jpg)
Cell-free mutant analysis combined with structure prediction of a
de
por adulto (o preço varia de acordo com o tamanho do grupo)